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KMID : 0357320000350050368
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Journal of the Korean Society for Microbiology
2000 Volume.35 No. 5 p.368 ~ p.368
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Antituberculosis Drug Resistance in Korea, 1998-1999
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배길한:Bai Gill-Han
배길한:Bai Gill-Han/박영길:Park Young-Kil/이향규:Lee Hyang-Kyu/김상재:Kim Sang-Jae
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Abstract
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Nation-wide sample survey based on pulmonary tuberculosis patients registered in 245 health cen-ters in Korea was conducted to measure the pre-valence of antituberculosis drug resistance and to assess its impact on treatment outcome under the National Tuberculosis Programme. Assuming a 15% drop in sampled cases, the sample numbers finally required for this survey was estimated at 2,132 cases with 1.3% precision and 95% probability, which could be selected systema-tically in all health centers throughout the country during the 5-month period from 1 October to 28 February 1999. Total 2,653 M. tuberculosis were isolated from 3,008 sputum-positive cases sampled and submi-tted to the drug susceptibility testing (DST). Out of 2,370 new cases initial drug resistance (IDR) to one or nthre antituberculosis chugs was found 258 (10.9%, 9.6-12.1% at 95% CO where the majority had resistance to one drug (160/258, 62.0%). IDR to 1, 2, 3, 4, and 5 and more dings was 6.8%, 2.1%, 1.1%, 0.6%, and 0.3% respectively; any
INH resistance was found in 8.6%; any SM, 3.1%; any RMP, 3.0%; may EMS, 1.1%; any INH+RMP,
Acquired drug resistance (ADR) was found in 63 (22.3%, 17.4-27.1% at 95% CI) among 283 patients with history of chemotherapy. ADR to 1, 2, 3, 4, 5 or more drugs was 9.9%, 6.7%, 2.1%, 1.8%, and 1.8% respectively, any INH, 17.3%; any RMP, 10.3%; any 1NH+RMP, 7.4%; any SM, 6.7%; any EMB, 3.5% in order. The overall IDR of male patients was 11.8% (178/1,512), which was not significantly higher than that of female patients (9.3%, 80/858, p00.05). The general trend by age group was not signifycant (p>0.10). Compared with the data from the 1994 survey (11.3% in 1DR, 10.1-12.5% at 95% CI) conducted in the same method, the resistance to antitu-berculosis drugs in Korea has not been changed signifycantly. The present study also reaffirmed the inverse relationship of the drug resistance rate with the efficiency of a treatment programme.
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